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[Not Available].

Nicolas Venisse1, Audrey Boulamery2,

  • 1Service de Toxicologie et Pharmacocinétique, CHU, Poitiers, France.

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Summary
This summary is machine-generated.

Therapeutic drug monitoring (TDM) of aminoglycoside antibiotics is essential for treating gram-negative infections, improving efficacy and reducing toxicity. While evidence supports TDM for multiple daily doses, it is also recommended for once-daily regimens.

Keywords:
aminoglycosidesaminosidespharmacocinétiquepharmacodynamicspharmacodynamiepharmacokineticssuivi thérapeutique pharmacologiquetherapeutic drug monitoring

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Pharmacy

Context:

  • Aminoglycosides are crucial antibiotics for gram-negative bacterial infections.
  • These antibiotics exhibit significant inter-individual pharmacokinetic variability.
  • Clinical effectiveness is high, but toxicity is a major concern.

Purpose:

  • To evaluate the role and evidence supporting therapeutic drug monitoring (TDM) for aminoglycoside antibiotics.
  • To assess the cost-effectiveness and impact of TDM on efficacy and toxicity.
  • To provide recommendations for TDM implementation in clinical practice.

Summary:

  • Therapeutic drug monitoring (TDM) of aminoglycosides administered multiple times daily is cost-effective, enhancing efficacy and minimizing toxicity.
  • Clear relationships exist between aminoglycoside concentration and clinical effect.
  • TDM is considered essential for aminoglycosides given in multiple daily doses.

Impact:

  • TDM implementation can optimize aminoglycoside therapy, leading to better patient outcomes.
  • Reduced toxicity and improved treatment efficacy are key benefits of TDM.
  • While evidence for once-daily dosing is less robust, TDM is still highly recommended.