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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Audrey Boulamery¹, Nicolas Venisse², Chantal Le Guellec³

¹Laboratoire de Pharmacologie Médicale et Clinique, CHU Marseille, Université de la Méditerranée, Marseille, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring of teicoplanin is necessary for treating serious Gram-positive bacterial infections. Monitoring trough concentrations ensures optimal dosing for clinical success, especially with high variability.

Keywords:

suivi thérapeutique pharmacologique teicoplatin teicoplatine therapeutic drug monitoring

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Area of Science:

Pharmacology
Infectious Diseases
Microbiology

Context:

Teicoplanin is a critical glycopeptide antibiotic for severe Gram-positive bacterial infections.
Treatment involves a loading dose followed by maintenance doses.
Significant interindividual pharmacokinetic variability exists.

Purpose:

To evaluate the necessity of therapeutic drug monitoring (TDM) for teicoplanin.
To establish target trough concentrations for effective treatment.
To correlate drug levels with clinical success.

Summary:

High interindividual variability in teicoplanin pharmacokinetics necessitates TDM.
Therapeutic success is strongly linked to dose and trough concentrations.
Recommended trough concentrations are 10-15 mg/L or 20-40 mg/L, depending on measurement method and infection severity.

Impact:

TDM of teicoplanin is deemed 'necessary' for optimizing patient outcomes.
Ensuring adequate drug exposure increases clinical success rates.
This supports evidence-based guidelines for teicoplanin therapy.