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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

Hugues Modelon1, Elisabeth Frauger1, Delphine Laurenceau1

  • 1CEIP de Marseille (PACA-Corse, Centre associé), Fédération de Pharmacologie et de Toxicologie, CHU Timone, Marseille, France.

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Psychotropic drug use and abuse patterns reveal shifts towards methadone maintenance and altered illicit drug consumption methods. Illicit buprenorphine and benzodiazepine use, particularly clonazepam, are significant concerns.

Keywords:
addictionbenzodiazepinesbenzodiazépinesmaintenance treatmentopiacésopioidspharmacodépendancepsychotropic drugssubstances psychoactivestraitement de substitution

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Public Health

Context:

  • Data from the OPPIDUM (Observation des Produits Psychotropes Illicites ou Détournés de leur Utilisation Médicamenteuse) survey, an annual study on licit and illicit drug consumption.
  • Involved 3373 patients from 109 health centers in October 2004.
  • Focuses on psychotropic drug use and abuse among drug addicts.

Purpose:

  • To identify and characterize the patterns of psychotropic drug use and abuse in a population of drug addicts.
  • To analyze trends in the consumption of specific psychotropic substances, including opioids and benzodiazepines.
  • To highlight emerging risks associated with illicit drug use.

Summary:

  • Observed an increasing preference for methadone over high-dose buprenorphine in opioid maintenance treatment.
  • Noted changes in illicit drug administration routes, with an increase in snorting and a decrease in intravenous injection.
  • Documented shifts in benzodiazepine consumption, including decreased flunitrazepam and increased clonazepam use.
  • Identified illicit buprenorphine leading to dependence and concerning illicit use of benzodiazepines, especially clonazepam.

Impact:

  • Provides crucial insights into evolving drug use behaviors and treatment preferences.
  • Informs public health strategies for addiction treatment and harm reduction.
  • Highlights the need for targeted interventions regarding illicit buprenorphine and benzodiazepine abuse.