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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Marie-Dominique Tabone¹, Nathalie Le Guyader², Guy Leverger¹

¹Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau, Paris, France.

|July 10, 2016

Summary

This summary is machine-generated.

Pediatric antifungal use requires careful consideration of mycoses epidemiology and age-related pharmacokinetics. Limited data and rare approvals necessitate tailored strategies for safe and effective antifungal treatment in children.

Keywords:

antifongiques antifungals approval autorisation de mise sur le marché children cost coût infant neonates pédiatrie

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Last Updated: Mar 18, 2026

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Area of Science:

Pediatric pharmacology
Mycology
Infectious diseases

Context:

Antifungal use in children is complex due to varying mycoses epidemiology.
Pharmacokinetic data for most antifungals in pediatric populations are limited.
Few antifungal agents are approved for pediatric use in France.

Purpose:

To highlight the specific challenges of antifungal use in pediatric patients.
To emphasize the need for age-specific pharmacokinetic data and approved medications.
To underscore the importance of considering adverse events, drug interactions, and cost-effectiveness.

Summary:

Antifungal efficacy and safety in children are influenced by age-specific pharmacokinetics and differing adverse event profiles compared to adults.
Limited pharmacokinetic data and a scarcity of approved agents pose significant challenges in pediatric antifungal therapy.
Optimal antifungal strategies must be individualized, considering epidemiology, pharmacokinetics, safety, and economic factors.

Impact:

Informing the development of evidence-based guidelines for pediatric antifungal prescribing.
Guiding further research into pediatric antifungal pharmacokinetics and clinical efficacy.
Improving the safe and effective management of fungal infections in children.