Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

737
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
737
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

617
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
617
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.2K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.2K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.9K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.9K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.3K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.3K
Clinical Trials01:16

Clinical Trials

11.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Studies in Vibrations Causing Pulmonary Physical Signs.

Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association·2011
Same author

The Role of Forced Vibrations in the Production of Physical Signs.

Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association·2011
Same author

The application of tests for in-vivo isosensitivity of the red cells of newly born infants.

The Medical journal of Australia·2010
Same author

A new human iso-agglutinin subdividing the MN blood groups.

Nature·2010
Same author

The Relation of intestinal Absorption to Pulmonary Anthracosis.

The Journal of medical research·2009
Same author

EXPERIMENTAL PULMONARY TUBERCULOSIS IN THE DOG : THE EFFECT OF LARGE AMOUNTS OF TUBERCLE BACILLI OF BOVINE TYPE INTRODUCED DIRECTLY INTO THE LUNGS BY WAY OF THE AIR PASSAGES.

The Journal of experimental medicine·2009

Related Experiment Video

Updated: Mar 18, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K

Adaptive trials for tuberculosis: early reflections on theory and practice.

C M Montgomery1

  • 1Amsterdam Institute for Social Science Research, University of Amsterdam, Amsterdam, The Netherlands.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|July 10, 2016
PubMed
Summary

Adaptive designs (ADs) offer efficiency for tuberculosis (TB) trials but face implementation challenges in developing countries. Further research into patient experiences and contextual factors is crucial for successful adoption.

More Related Videos

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.4K
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
10:29

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

8.4K

Related Experiment Videos

Last Updated: Mar 18, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.4K
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
10:29

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

8.4K

Area of Science:

  • Clinical Trials
  • Tuberculosis Research
  • Biostatistics

Background:

  • Adaptive designs (ADs) are proposed for anti-tuberculosis (TB) treatment trials amidst evolving evidence standards.
  • Innovation in trial design is needed to address current challenges in TB research.

Purpose of the Study:

  • To contextualize ADs for TB clinical trials.
  • To explore the perspectives of professionals involved in AD trials within the TB field.

Main Methods:

  • Qualitative study design.
  • 24 in-depth interviews with professionals involved in AD trials.
  • Focus on professionals working in TB and non-TB trial settings.

Main Results:

  • Professionals view ADs as efficient but have concerns about suitability for TB.
  • Implementation challenges in developing countries include regulatory capacity, infrastructure, and informed consent.
  • Key concerns for AD success in TB include funding, interdisciplinary communication, and policy.

Conclusions:

  • Further empirical research on patient experiences with ADs, including informed consent, is necessary.
  • Understanding the context of innovation in trial design is critical for translating AD theory into practice for TB.
  • Addressing regulatory, infrastructural, and communication challenges is vital for successful AD implementation in TB trials.