Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Availability Heuristic

The Availability Heuristic

A heuristic is a general problem-solving framework (Tversky & Kahneman, 1974). You can think of these as mental shortcuts that are used to solve problems. Different types of heuristics are used in different types of situations, and the impulse to use a heuristic occurs when one of five conditions is met (Pratkanis, 1989):

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

<i>Territory health</i>: A transdisciplinary approach of environmental, plant, animal, and human health interdependencies in a rural landscape in France.

iScience·2026

Same author

Levamisole associated with linear IgA dermatosis.

Clinical toxicology (Philadelphia, Pa.)·2025

Same author

N-Ethylhexedrone: A very long and bad trip! A case series.

Journal of analytical toxicology·2024

Same author

Analytical methods and biomonitoring results in hair for the assessment of exposure to endocrine-disrupting chemicals: A literature review.

Chemosphere·2024

Same author

Dried Urine Spot Analysis for assessing cardiovascular drugs exposure applicable in spaceflight conditions.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2023

Same author

Bioavailability of dissolved and crushed single tablets of bictegravir, emtricitabine, tenofovir alafenamide in healthy adults: the SOLUBIC randomized crossover study.

The Journal of antimicrobial chemotherapy·2022

Same journal

Pharmacology of pruritus (pathophysiology, therapeutic targets).

Therapie·2026

Same journal

Barriers to prescribing methylphenidate for adults with ADHD: A qualitative study.

Therapie·2026

Same journal

[Self-medication and its factors amongst Navymen aboard surface ships of the French Navy at sea: A descriptive study].

Therapie·2026

Same journal

Subacute cutaneous lupus erythematosus induced by ticagrelor: Recurrence after rechallenge.

Therapie·2026

Same journal

Multiple HIV virological failures related to bictegravir-valproic acid interaction evidenced by therapeutic drug monitoring: A retrospective study.

Therapie·2026

Same journal

Indication-related misuse of oral fluoroquinolones in adults by general practitioners in France.

Therapie·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Sandrine Lefeuvre¹, Mohammed-Larbi Jelassi², Amine Benlmouden²

¹Laboratoire de Pharmacologie-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital EuropéenGeorgesPompidou, Paris, France; Université Paris Descartes, Paris, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring for posaconazole is recommended. Maintaining specific plasma concentrations optimizes efficacy for invasive fungal infections and prophylaxis, especially given absorption limits.

Keywords:

posaconazole suivi thérapeutique pharmacologique therapeutic drug monitoring

More Related Videos

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

Published on: December 28, 2016

Related Experiment Videos

Last Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

Published on: December 28, 2016

Area of Science:

Pharmacology
Mycology
Clinical Therapeutics

Context:

Posaconazole is a systemic antifungal used for invasive fungal infections (IFI) and prophylaxis in immunocompromised patients.
It has been marketed in France since 2006.
A concentration-efficacy relationship is suggested by literature, but concentration-toxicity is unclear due to safety and achievable levels.

Purpose:

To review the concentration-efficacy relationship of posaconazole.
To discuss the challenges and recommendations for posaconazole dosing and monitoring.

Summary:

For curative treatment of IFI, maintaining posaconazole trough plasma concentrations between 0.5-1.5 mg/L appears linked to efficacy.
For prophylaxis, a threshold of 0.5 mg/L suggests minimal exposure, though this target requires further definition.
Oral absorption saturation above 800 mg limits dose adjustments, highlighting the utility of Therapeutic Drug Monitoring (TDM).

Impact:

Recommends Therapeutic Drug Monitoring (TDM) for posaconazole to optimize patient outcomes.
Provides target concentration ranges for both curative and prophylactic use.
Addresses limitations in achieving desired posaconazole concentrations due to absorption saturation.