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Updated: Mar 18, 2026

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
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Axillary node metastatic carcinoma without definitive primary: a case report.

Spencer R Anderson1, Charles S Scarborough2

  • 1Mercer University School of Medicine, Columbus, GA, United States.

International Journal of Surgery Case Reports
|July 11, 2016
PubMed
Summary

Cancer of unknown primary (CUP) can present atypically. This case highlights a young female with metastatic breast cancer diagnosed without an identifiable primary tumor, emphasizing thorough investigation for effective treatment.

Keywords:
AxillaryBreastCUPCase reportMetastatic carcinoma

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Cancer of unknown primary (CUP) accounts for up to 5% of malignant diagnoses.
  • CUP is defined as metastatic cancer without a detectable primary tumor, often adenocarcinoma.
  • Typical CUP presentation involves older patients with comorbidities and poor prognosis.

Purpose of the Study:

  • To report an atypical case of Cancer of Unknown Primary (CUP).
  • To highlight the diagnostic challenges and importance of thorough investigation in CUP cases.
  • To emphasize that CUP can occur in younger individuals without systemic symptoms.

Main Methods:

  • Histopathological examination and immunohistochemical staining of an axillary mass.
  • Comprehensive imaging including mammography, MRI, and PET scan to identify a primary tumor.
  • Review of clinical presentation and diagnostic workup for CUP.

Main Results:

  • A 38-year-old female presented with an axillary mass, diagnosed as metastatic carcinoma.
  • Extensive imaging failed to identify a primary tumor or distant metastases.
  • Immunohistochemistry confirmed metastatic breast carcinoma, despite no identifiable breast primary.

Conclusions:

  • Cancer of unknown primary can present atypically in younger patients.
  • Thorough diagnostic investigation is crucial for identifying the primary tumor in CUP cases.
  • Accurate diagnosis aids in selecting appropriate treatment regimens for improved patient outcomes.