Optic nerve integrity as a visuospatial cognitive predictor in Parkinson's disease
Jae Jung Lee1, Na-Young Shin2, Yoonju Lee3
1Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Republic of Korea.
Parkinsonism & Related Disorders
|July 11, 2016
Summary
Parkinson's disease (PD) patients show reduced optic nerve integrity. This optic nerve damage may predict future visuospatial cognitive decline in individuals with PD.
Area of Science:
- Neuroscience
- Radiology
- Neurology
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
- Optic nerve damage is increasingly recognized in neurodegenerative conditions.
- Assessing optic nerve integrity may offer insights into cognitive changes in PD.
Purpose of the Study:
- To investigate the microstructural integrity of the optic nerve in de novo Parkinson's disease (PD) patients.
- To determine if optic nerve integrity predicts cognitive decline in PD.
- To utilize diffusion tensor imaging (DTI) for assessing optic nerve integrity.
Main Methods:
- Enrolled 82 de novo PD patients, 36 drug-induced parkinsonism (DIP) patients, and 36 controls.
- Measured optic nerve fractional anisotropy (FA) and apparent diffusion coefficient (ADC) using DTI.
- Analyzed longitudinal cognitive changes in PD patients based on optic nerve integrity.
Main Results:
- PD patients exhibited significantly lower optic nerve FA and higher ADC compared to DIP and controls.
- Optic nerve integrity did not correlate with motor severity, dopamine transporter activity, olfaction, or baseline cognition.
- Lower FA in the optic nerve predicted a significant decline in the Clock Drawing Test performance over time in PD patients.
Conclusions:
- Microstructural integrity of the optic nerve is compromised in PD patients.
- Optic nerve integrity serves as a potential predictor of visuospatial cognitive dysfunction in PD.
- DTI assessment of the optic nerve may aid in understanding and predicting cognitive outcomes in Parkinson's disease.
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