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Related Experiment Videos

[Corticosteroids and cerebral vessel permeability during embryonic development].

D Ribatti, D Virgintino

    Medicina (Florence, Italy)
    |January 1, 1989
    PubMed
    Summary

    Cortisol exposure damages the developing blood-brain barrier (BBB) in chick embryos, increasing vascular permeability. This disruption impairs the BBB's ability to block tracer leakage, impacting neural development.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Endocrinology

    Context:

    • The blood-brain barrier (BBB) is crucial for protecting the central nervous system.
    • Cortisol, a stress hormone, can influence developmental processes.
    • Chick embryo models offer a window into early neural development.

    Purpose:

    • To investigate the microscopic effects of cortisol on the developing blood-brain barrier (BBB).
    • To assess vascular permeability using horseradish peroxidase (HRP) as a marker.
    • To understand how cortisol impacts BBB maturation in the chick embryo optic tectum.

    Summary:

    • Cortisol treatment was administered to chick embryos on the 8th and 10th incubation days.
    • Horseradish peroxidase (HRP) was injected intracardially on the 15th and 21st incubation days to evaluate BBB integrity.
    • Cortisol exposure significantly damaged the BBB maturation process, leading to HRP extravasation.

    Impact:

    • Cortisol disrupts the normal development and function of the blood-brain barrier.
    • Impaired BBB integrity allows for increased leakage of substances into the brain.
    • Findings suggest potential mechanisms for cortisol-induced neurodevelopmental alterations.

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