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Reversible Cerebral Atrophy in Infantile Tremor Syndrome
Rajesh Gupta1, Ashish Pathak, Jagdish Mandliya
1Department of Pediatrics. *Radiology and #Biochemistry, RD Gardi Medical College, Ujjain, MP, India. Correspondence to: Dr Rajesh Gupta, B 6/5, Doctors quarters, RD Gardi Medical College, Surasa, Ujjain, MP, India. drrajesh93@gmail.com.
Insights
Infantile Tremor Syndrome (ITS) in children can cause reversible brain changes. Neuroimaging shows diffuse cerebral atrophy that improves with treatment, indicating a positive prognosis.
Area of Science:
- Pediatric Neurology
- Neuroimaging
- Child Neurology
Background:
- Infantile Tremor Syndrome (ITS) is a neurological disorder affecting infants.
- Understanding the neurobiological underpinnings of ITS is crucial for effective management.
Observation:
- This study observed serial MRI brain scans in three children diagnosed with ITS.
- Assessments were conducted at the onset of illness and after treatment initiation.
Findings:
- Children with ITS exhibited mild to severe diffuse cerebral atrophy on initial MRI scans.
- Follow-up MRI scans revealed a reversal of cerebral atrophy, with neuroimaging returning to normal.
Implications:
- The findings suggest that cerebral atrophy in ITS is a reversible condition.
- This reversibility indicates a potentially favorable prognosis for affected children with timely treatment.
Background:
We report changes in MRI brain of children with Infantile Tremor Syndrome (ITS) at the onset of illness and following treatment.
Case Characteristics:
Three children with infantile tremor syndrome were assessed for changes in brain neuroimaging at admission and at follow-up visit. On MRI, all children had mild to severe diffuse cerebral atrophy, which reverted back to normal on follow-up visits.
Outcome:
Children with infantile tremor syndrome have reversible diffuse cerebral atrophy on neuroimaging.
