Can central neuropeptides be implicated in carotid sinus reflex hypersensitivity?
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Updated: Oct 23, 2026

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
Published on: September 22, 2011
M W Baig1, G C Kaye, E J Perrins
1Department of Medical Cardiology, General Infirmary, Leeds, England, U.K.
Abstract:
Carotid sinus reflex hypersensitivity involves profound and intermittent changes in heart rate and blood pressure associated with symptoms of dizziness and syncope. This involves a reflex arc in which the main defect is believed to lie within the central nervous system. The discovery of classical and peptidergic neurotransmitters within the same neurone, and the presence of these peptides within the central nervous system raises the possibility that carotid sinus reflex hypersensitivity may be related to an abnormality of peptide distribution or function.
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