Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

135.0K
Overview
135.0K
Introduction to Metabolism01:30

Introduction to Metabolism

3.4K
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
3.4K
Overview of Metabolism01:40

Overview of Metabolism

40.7K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
40.7K
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

4.5K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pyruvylation of STAT1 inhibits anti-viral immunity: Prospects for new anti-viral therapeutics.

Molecular cell·2026
Same author

4-Octyl itaconate blocks STAT3-induced ACE2 expression to reduce uptake of SARS-CoV-2.

Biochemical pharmacology·2026
Same author

Retraction Note: MAVS is a sensor of fumarate during antiviral immunity.

Nature microbiology·2026
Same author

Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages.

Cellular & molecular immunology·2026
Same author

Mitochondria target the plasma membrane to cause mitoxyperiosis.

Cell research·2026
Same author

Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production.

Scientific reports·2025

Related Experiment Video

Updated: Mar 18, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

1.0K

A guide to immunometabolism for immunologists.

Luke A J O'Neill1, Rigel J Kishton2, Jeff Rathmell2

  • 1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Nature Reviews. Immunology
|July 12, 2016
PubMed
Summary

Immunometabolism research reveals how changes in immune cell metabolism impact function. Understanding these metabolic pathways offers new insights into the immune system in both health and disease.

More Related Videos

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

1.1K
A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
07:41

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

Published on: February 4, 2017

9.0K

Related Experiment Videos

Last Updated: Mar 18, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

1.0K
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

1.1K
A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
07:41

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

Published on: February 4, 2017

9.0K

Area of Science:

  • Immunology
  • Metabolic pathways
  • Cellular metabolism

Background:

  • Recent findings highlight the field of immunometabolism.
  • Immunometabolism involves changes in intracellular metabolic pathways within immune cells.
  • These metabolic alterations significantly affect immune cell function.

Purpose of the Study:

  • To provide a refresher on major metabolic pathways in immunometabolism.
  • To illustrate how specific metabolite changes influence immune cell responses.
  • To elucidate the complex interplay between metabolic reprogramming and immunity.

Main Methods:

  • Review of key metabolic pathways: glycolysis, tricarboxylic acid (TCA) cycle, pentose phosphate pathway.
  • Review of fatty acid oxidation, fatty acid synthesis, and amino acid metabolism.
  • Inclusion of specific examples demonstrating metabolite-driven immune cell responses.

Main Results:

  • Detailed explanation of six major metabolic pathways involved in immunometabolism.
  • Examples showing how precise metabolite alterations shape immune cell function.
  • Emerging evidence points to a complex interplay between metabolic reprogramming and immune responses.

Conclusions:

  • Metabolic reprogramming is intricately linked with immune cell function.
  • Understanding immunometabolism provides a new dimension to the study of the immune system.
  • This field offers critical insights into immune system function in health and disease.