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Updated: Mar 18, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
When we should say no to TAVR-Defining the line between utility and futility
Zubair A Khan1, Janah Aji1, Armaghan Soomro2
1Cooper University Hospital, Camden, NJ 08109, USA.
Insights
Patients with prior coronary artery bypass surgery (CABG) undergoing transcatheter aortic valve replacement (TAVR) face increased risks. This case highlights avoiding transapical TAVR to prevent injury to epicardial collateral circulation.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Prior coronary artery bypass surgery (CABG) is common in severe symptomatic aortic stenosis (AS) patients unsuitable for traditional surgery.
- These patients exhibit higher peri-operative risks compared to those without prior CABG.
- Concomitant peripheral arterial disease (PAD) and patent left internal mammary artery (LIMA) grafts complicate TAVR access.
Observation:
- An 84-year-old female with prior CABG and severe PAD presented with severe symptomatic AS.
- She underwent transapical TAVR, resulting in acute myocardial injury due to damage to apical epicardial collateral circulation.
- This complication underscores the vulnerability of coronary collateral vessels during transapical procedures.
Findings:
- The case demonstrates a rare complication of transapical TAVR in a patient with extensive prior CABG and PAD.
- Damage to epicardial collateral circulation led to acute myocardial injury.
- Recognition of coronary collateralization is crucial for procedural planning and patient safety.
Implications:
- Transapical TAVR may need to be avoided in patients with prior CABG and compromised coronary collateralization.
- Peri-procedural angiographic or fluoroscopic guidance is essential to prevent inadvertent injury to epicardial vessels.
- Careful patient selection and procedural technique are paramount to minimize risks in complex TAVR cases.
Abstract:
History of prior coronary artery bypass surgery (CABG) is a frequent scenario encountered in patients with severe symptomatic aortic stenosis deemed inoperable and referred for transcatheter aortic valve replacement (TAVR). Aside from indices of frailty and other comorbidities, these patients remain at higher risk for peri-operative mortality and morbidity compared to their counterparts without prior CABG. Presence of concomitant peripheral arterial disease and patent left internal mammary artery (LIMA) graft pose further access related challenges. We present a case of an 84-year-old female with prior CABG and severe PAD who underwent transapical TAVR for severe symptomatic AS sustaining an acute myocardial injury from damage to her apical epicardial collateral circulation. The case entails the importance of recognition of epicardial coronary collateralization where a transapical approach is best avoided or further aided by utilization of peri-procedural angiographic/fluoroscopy guidance to avoid epicardial vascular injury.
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