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Updated: Mar 18, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
A solid self-nanoemulsifying system of the BCS class IIb drug dabigatran etexilate to improve oral bioavailability
Fujuan Chai1, Linlin Sun2,3, Yafei Ding4
1Pharmaceutical Research Institute, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Aim:
To develop dabigatran etexilate (DE)-loaded self-nanoemulsifying drug delivery systems (SNEDDS) for the prevention of stroke and thromboembolism.
Materials & Methods:
SNEDDS were optimized by ternary phase diagrams and then further solidified into dispersible tablets. In vitro dissolution was analyzed by a phase distribution study. In situ absorption and in vivo pharmacokinetic studies were tested in male Sprague-Dawley rats.
Results:
The phase distribution study showed that more than 60% of DE was retained in the oil phase. Dissolution rate was dramatically enhanced without significant precipitation (<30%) in simulated intestinal fluid. Optimized SNEDDS had 531.80% relative bioavailability compared with Pradaxa(®) capsules (a commercial DE product).
Conclusion:
The developed SNEDDS are promising materials for improving the dissolution and oral bioavailability of BCS class IIb drugs.
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