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A fatal case of paramethoxyamphetamine poisoning and its detection in hair
Moonhee Jang1, Wonkyung Yang1, Sujin Jeong1
1National Forensic Service, 139 Jiyang-ro, Yangcheon-Gu, Seoul 158-707, Republic of Korea.
Abstract:
Paramethoxyamphetamine (PMA) is a phenethylamine derivative that is structurally related to 3,4-methylenedioxymethamphetamine (MDMA), but has higher toxicity than MDMA. Here, we report a fatal intoxication case involving PMA. A 36-year-old man was found dead in a hotel room. Toxicological analysis revealed that PMA concentrations were 0.57 and 0.59mg/L in peripheral and heart blood, respectively. Ketamine and diazepam were also detected in his blood. Based on toxicological results and autopsy findings, the cause of death was determined to be acute fatal intoxication with PMA. Hair analysis using gas chromatography/mass spectrometry was performed and PMA was detected at a concentration of 20.1ng/mg after methanol extraction for 20h. This is the first report of the determination of PMA concentration in the hair from a drug abuser.
Insights
This case report details a fatal paramethoxyamphetamine (PMA) intoxication. PMA, a toxic phenethylamine, was identified in blood and hair, confirming it as the cause of death.
Area of Science:
- Forensic Toxicology
- Pharmacology
Background:
- Paramethoxyamphetamine (PMA) is a phenethylamine derivative with higher toxicity than MDMA.
- Phenethylamine derivatives are frequently encountered in forensic toxicology cases.
Observation:
- A fatal intoxication case involving a 36-year-old male is presented.
- The deceased had elevated PMA concentrations in peripheral (0.57mg/L) and heart blood (0.59mg/L).
- Ketamine and diazepam were also detected in the blood samples.
Findings:
- The cause of death was determined to be acute fatal intoxication with PMA.
- Gas chromatography/mass spectrometry analysis detected PMA in hair at 20.1ng/mg.
- This is the first report quantifying PMA in the hair of a drug abuser.
Implications:
- This case highlights the significant toxicity of PMA and its potential as a cause of fatal overdose.
- Hair analysis provides a valuable tool for detecting chronic or past PMA use.
- Understanding PMA's toxicological profile is crucial for forensic investigations and public health awareness.
