Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
Teeth01:15

Teeth

2.1K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
2.1K
MicroRNAs01:22

MicroRNAs

24.5K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erosive tooth wear - knowledge and treatment preferences among dental hygienists.

Acta odontologica Scandinavica·2026
Same author

Impact of Time of Day on Dry Eye Disease: Findings from a Large Dry Eye Clinic Cohort.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

From Images to Specimens: The Impact of Tactile, Three-Dimensional Learning in Dental Anatomy.

Dentistry journal·2026
Same author

Evaluating digital resources as a supplement to traditional anatomy teaching in dental education.

Frontiers in dental medicine·2026
Same author

Histogenetics in Teaching the Complexity of Developmental Biology to Dental Students: A Study Merging Traditional and Current Approaches.

Dentistry journal·2026
Same author

Corrigendum.

Ophthalmology·2026

Related Experiment Video

Updated: Mar 18, 2026

Studying Orthodontic Tooth Movement in Mice
07:17

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

1.7K

MicroRNAs: Modulators of Tooth Development.

Cuong Khuu, Minou Nirvani, Tor P Utheim

  • 1Department of Oral Biology, University of Oslo, P.O. Box 1052 Blindern, 0316 Oslo, Norway. amer.sehic@odont.uio.no.

Microrna (Shariqah, United Arab Emirates)
|July 12, 2016
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are crucial for tooth development, regulating gene expression and fine-tuning signaling networks. Studying animal models reveals their essential role in dental hard tissue formation and potential links to congenital dental defects.

More Related Videos

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

8.7K
Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

1.4K

Related Experiment Videos

Last Updated: Mar 18, 2026

Studying Orthodontic Tooth Movement in Mice
07:17

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

1.7K
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

8.7K
Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

1.4K

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Tooth development involves complex epithelial-mesenchymal interactions.
  • MicroRNAs (miRNAs) are key regulators of gene expression in biological pathways.
  • Mutations in genes affecting tooth development are linked to congenital dental defects.

Purpose of the Study:

  • To review animal model studies on the function of miRNAs in tooth development.
  • To highlight the role of miRNAs in fine-tuning and regulating developmental networks.
  • To discuss the implications for understanding congenital dental defects.

Main Methods:

  • Literature review of studies utilizing animal models.
  • Analysis of findings related to miRNA function in tooth morphogenesis and differentiation.
  • Emphasis on network regulation and fine-tuning by miRNAs.

Main Results:

  • Global miRNA processing knockouts in animal models show defects mirroring essential fine-tuning for dental hard tissue formation.
  • miRNAs are involved in regulating tooth morphogenesis by fine-tuning signaling networks.
  • The precise role of individual miRNAs in tooth differentiation and morphogenesis requires further investigation.

Conclusions:

  • miRNAs play a significant role in tooth development, acting as crucial fine-tuners of genetic networks.
  • Further research into specific miRNA functions and mutations can enhance understanding of dental defects.
  • Insights from tooth development may have broader biological relevance for other epithelial-derived organs.