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A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood

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FDG-PET hyperactivity pattern in anti-NMDAr encephalitis.

Jan Novy¹, Gilles Allenbach², Christian G Bien³

¹Neurology service, Department of clinical neurosciences, CHUV, University of Lausanne, Lausanne, Switzerland.

Journal of Neuroimmunology

|July 12, 2016

Summary

This summary is machine-generated.

Fluorodeoxyglucose-positron emission tomography (FDG-PET) reveals characteristic brain metabolism patterns in anti-N-methyl-D-aspartate receptor (anti-NMDAr) encephalitis. This study confirms an anteroposterior gradient and highlights increased caudate nucleus uptake.

Keywords:

Inflammation NMDA Psychiatry

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Area of Science:

Neuroscience
Neurology
Radiology

Background:

Anti-N-methyl-D-aspartate receptor (anti-NMDAr) encephalitis is an autoimmune disorder affecting the brain.
Previous studies suggest FDG-PET may show an anteroposterior metabolic gradient, but basal ganglia involvement is debated.

Purpose of the Study:

To investigate the glucose metabolism patterns using FDG-PET in patients with anti-NMDAr encephalitis.
To compare FDG-PET findings with healthy controls and analyze the involvement of basal ganglia.

Main Methods:

Analysis of FDG-PET scans from 5 consecutive episodes of serologically confirmed anti-NMDAr encephalitis.
Comparison of metabolic patterns with those of healthy control subjects.

Main Results:

Confirmed the previously suggested anteroposterior metabolic gradient in anti-NMDAr encephalitis.
Observed a significant increase in FDG uptake in the caudate nuclei, irrespective of episode intensity or delay from symptom onset.

Conclusions:

FDG-PET demonstrates a characteristic cortical and sub-cortical metabolism pattern in anti-NMDAr encephalitis.
FDG-PET can be a valuable tool in diagnosing suspected cases of anti-NMDAr encephalitis, particularly by showing basal ganglia involvement.