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Updated: Mar 18, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
Published on: June 23, 2022
Beyond "turn-on" readout: from zero background to signal amplification by combination of magnetic separation and
1Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, China. xiayuns@mail.ahnu.edu.cn.
Abstract:
By magnetic separation and subsequent plasmon enhanced fluorescence, an assay platform with a signal output from completely "zero" background to fluorescence amplification is achieved, using quantum dots as reporters. So, it well breaks through the conventional "turn-on" strategy in both lower and upper limits. The sensitivity for hyaluronidase sensing is enhanced 10(4)-10(6) times as compared with previous fluorescence methods.

