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[Severe infection by methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin: reports of

Martín Brizuela1, Guadalupe Pérez2, Silvina Ruvinsky2

  • 1Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina. martin.brizuela1984@gmail.com.

Archivos Argentinos De Pediatria
|July 12, 2016
PubMed

Insights

Severe Staphylococcus aureus infections in children can stem from Panton-Valentine leukocidin-producing strains. Early diagnosis and treatment are crucial for managing these serious pediatric infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Microbial Pathogenesis

Background:

  • Staphylococcus aureus is a leading cause of pediatric infections in both community and hospital settings.
  • The Panton-Valentine leukocidin (PVL) is a key virulence factor associated with severe S. aureus infections.
  • Both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) S. aureus can produce PVL, though frequencies vary.

Observation:

  • This study details two pediatric cases of severe infection caused by PVL-producing methicillin-sensitive Staphylococcus aureus (MSSA).
  • The children presented with significant musculoskeletal and endovascular complications.
  • These cases highlight the potential severity of PVL-positive MSSA infections.

Findings:

  • Panton-Valentine leukocidin-producing methicillin-sensitive Staphylococcus aureus can cause severe invasive infections in children.
  • Musculoskeletal and endovascular complications are significant risks associated with these infections.
  • The presence of PVL in MSSA strains contributes to disease severity.

Implications:

  • Early and accurate diagnosis of PVL-producing S. aureus infections is critical for effective management.
  • Prompt antibiotic therapy and surgical intervention are essential for improving patient outcomes.
  • Continued epidemiological surveillance is necessary to monitor the prevalence of PVL-positive S. aureus strains in pediatric populations.
Keywords:
Invasive diseaseMethicillin resistancePanton-Valentine leukocidinStaphylococcus aureus

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