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Low serum 25-hydroxyvitamin D level and risk of urinary tract infection in infants

Jianhuan Yang1, Guangdao Chen, Dexuan Wang

  • 1Department of Pediatric, Zhujiang Hospital of Southern Medical University, Guangzhou Department of Pediatric, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Department of Pediatric, Central Hospital of Panyu District, Guangzhou Department of Clinical Laboratory, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Medicine
|July 12, 2016
PubMed

Insights

Infant vitamin D deficiency significantly increases the risk of urinary tract infections (UTIs). Supplementation with vitamin D was associated with a reduced likelihood of UTIs, suggesting its potential role in prevention.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Nutritional Science

Background:

  • Urinary tract infections (UTIs) are common in infants.
  • Vitamin D plays a crucial role in immune function.
  • The relationship between vitamin D levels and UTI risk in infants requires further elucidation.

Purpose of the Study:

  • To investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of first-time UTI in infants.
  • To determine if vitamin D deficiency is a risk factor for UTI in this population.

Main Methods:

  • A case-control study involving 238 infants (1-12 months old): 132 with a first UTI episode and 106 controls.
  • Serum 25(OH)D levels were measured via blood sampling.
  • Multivariate logistic regression analysis was used to assess the relationship between 25(OH)D levels and UTI odds, controlling for potential confounders.

Main Results:

  • Infants with UTI had significantly lower mean serum 25(OH)D levels (29.09 ng/mL) compared to controls (38.59 ng/mL).
  • Serum 25(OH)D levels below 20 ng/mL were positively associated with increased odds of UTI (OR 5.619).
  • Vitamin D supplementation showed a protective effect, associated with decreased UTI likelihood (OR 0.298).

Conclusions:

  • Serum 25(OH)D deficiency in infants is linked to a higher risk of developing UTIs.
  • Vitamin D supplementation may be a potential strategy to reduce the incidence of UTIs in infants.
  • Further interventional studies are recommended to confirm the efficacy of vitamin D supplementation for UTI prevention.

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