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Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth.

Y Wang1,2, X Hong3, J Wang2

  • 1Scientific Research Center for Translational Medicine, Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

Oncogene
|July 12, 2016
PubMed
Summary

A novel Rheb mutation (Rheb-Y35N) drives cancer by activating mTORC1 and MAPK pathways, conferring resistance to rapamycin. This Rheb mutation promotes aggressive tumor growth, suggesting combined mTORC1 and MAPK inhibition as a therapeutic strategy.

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