Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

19.2K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
19.2K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

611
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
611
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

63
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
63
Mutations01:35

Mutations

45.3K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
45.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anesthesia Education on Postoperative Delirium Guidelines and Consensuses for the Adult Patient.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses·2026
Same author

A systematic review and meta-analysis of shRNA-IL-6-engineered CAR-T cells for B-cell acute lymphoblastic leukemia: a stepping stone toward risk-free immunotherapy.

Bioscience reports·2026
Same author

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP-00).

The Prostate·2026
Same author

Exploring the behavioural and biochemical effects of cordycepin in PTSD-like behaviour using an early life stress mouse model.

Biochemical and biophysical research communications·2026
Same author

Pharmacy in Australia: are we research ready?

The International journal of pharmacy practice·2026
Same author

Evaluation of the use of chatbots as simulated patients in capstone clinical pharmacy education: A pilot study.

Currents in pharmacy teaching & learning·2026

Related Experiment Video

Updated: Mar 18, 2026

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
04:53

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors

Published on: August 25, 2022

2.2K

Protection against Radiotherapy-Induced Toxicity.

Susan Hall1,2, Santosh Rudrawar3,4, Matthew Zunk5,6

  • 1Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. s.hall@griffith.edu.au.

Antioxidants (Basel, Switzerland)
|July 12, 2016
PubMed
Summary

Radiation therapy is common for cancer but causes severe side effects. This review examines current and emerging radioprotectant agents to mitigate radiation-induced toxicities.

Keywords:
inflammationoxidative stressradiotherapytoxicity

More Related Videos

Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
05:39

Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine

Published on: April 5, 2024

1.3K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

Related Experiment Videos

Last Updated: Mar 18, 2026

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
04:53

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors

Published on: August 25, 2022

2.2K
Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
05:39

Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine

Published on: April 5, 2024

1.3K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

Area of Science:

  • Oncology
  • Radiology
  • Pharmacology

Background:

  • Radiation therapy is a cornerstone in cancer treatment, used in up to 60% of patients.
  • Radiation therapy can lead to severe and permanent adverse effects.
  • Existing radioprotective agents offer limited protection against radiation-induced toxicities.

Purpose of the Study:

  • To review and summarize evidence on established radioprotectant agents.
  • To evaluate emerging therapies for preventing radiation-induced toxicities.
  • To provide a comprehensive overview of radioprotective strategies.

Main Methods:

  • Systematic literature search for clinical and preclinical studies.
  • Analysis of evidence for known radioprotective compounds.
  • Evaluation of emerging agents with potential radioprotective properties.

Main Results:

  • Identified a limited number of clinically used radioprotectant agents.
  • Highlighted several promising emerging therapies for radiation protection.
  • Summarized the efficacy and limitations of current and future radioprotective agents.

Conclusions:

  • There is a need for more effective radioprotective agents.
  • Emerging therapies show promise in reducing radiation-associated toxicities.
  • Further research is crucial to develop novel radioprotectors for cancer patients.