Related Experiment Video
Updated: Mar 18, 2026
Elucidating the Metabolism of 2,4-Dibromophenol in Plants
Published on: February 10, 2023
Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity
Hongbing Liu1, Katheryn Lohith1, Margaret Rosario1
1Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
None:
Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL(-1) minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.
