The application of prodrug-based nano-drug delivery strategy in cancer combination therapy

Area of Science:

• Nanomedicine
• Oncology
• Drug Delivery Systems

Background:

• Single-agent cancer therapy often leads to multidrug resistance and severe side effects.
• Combination therapies targeting multiple signaling pathways are a key research focus.
• Prodrug-based nano-drug delivery systems (P-N-DDSs) offer a promising platform for advanced cancer treatment.

Purpose of the Study:

• To review the application of P-N-DDSs in cancer combination therapy.
• To explore combinations of prodrugs with chemotherapeutics, other agents, and nucleic acids.
• To discuss the integration of different therapy types, such as chemotherapy and phototherapy, using P-N-DDSs.

Main Methods:

• Literature review of recent studies on prodrug-based nanoparticulate drug delivery strategies.
• Analysis of P-N-DDSs employed in various combination cancer therapy approaches.
• Discussion of case examples demonstrating the feasibility of these technologies.

Main Results:

• P-N-DDSs are effectively utilized for combining various therapeutic agents for cancer treatment.
• These systems facilitate the co-delivery of chemotherapeutics, other drugs, and nucleic acids.
• Combination of chemotherapy with other modalities like phototherapy is feasible using P-N-DDSs.

Conclusions:

• P-N-DDSs represent a viable and advanced strategy for combination cancer therapy.
• These systems hold significant potential for overcoming multidrug resistance and improving treatment outcomes.
• Further research and development in P-N-DDSs are crucial for their clinical translation.