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Safety of Secretin Administration in Children

Karoly Horvath1, Beth Loveridge-Lenza, B Randall Brenn

  • 1From the *Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA; †Division of Gastroenterology and Nutrition, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE; ‡Center for Pediatric Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL; §K. Hovnanian Children's Hospital, Jersey Shore University Hospital, Neptune, NJ; ∥Department of Anesthesia, Thomas Jefferson University, Philadelphia, PA; and ¶Departments of Anesthesia and Biomedical Research and #Gastroenterology Laboratory, Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.

Pancreas
|July 12, 2016
PubMed

Insights

Secretin pancreatic function tests (sPFTs) during pediatric upper gastrointestinal endoscopy (EGD) are safe, causing only minor, clinically insignificant hemodynamic changes and a slight increase in procedure time.

Area of Science:

  • Pediatric Anesthesiology
  • Gastroenterology
  • Diagnostic Procedures

Background:

  • Upper gastrointestinal endoscopy (EGD) is a common procedure in children.
  • Secretin pancreatic function tests (sPFTs) are used to assess pancreatic exocrine function.
  • Hemodynamic stability during pediatric procedures is crucial.

Purpose of the Study:

  • To compare hemodynamic parameters in children undergoing EGD with and without sPFTs.
  • To evaluate the safety and impact of sPFTs on vital signs during pediatric EGD.
  • To assess the effect of sPFTs on procedure and anesthesia duration.

Main Methods:

  • Retrospective analysis of electronic anesthesia records.
  • Comparison of hemodynamic data between a secretin group (n=186) and a control group (n=136).
  • Age- and sex-matched control group without sPFTs.

Main Results:

  • No significant demographic differences between groups, though the secretin group had lower height and BMI.
  • sPFTs extended procedure time by an average of 3 minutes.
  • Heart rate increased by an average of 7 bpm in the secretin group; blood pressure changes were mild and not clinically significant.
  • No complications reported in either group.

Conclusions:

  • Secretin PFT is a safe procedure in pediatric EGD.
  • sPFTs cause minimal, clinically insignificant hemodynamic alterations.
  • The procedure slightly prolongs anesthesia and procedural time without adverse effects.
Abstract

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