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The association between hypovitaminosis D and pediatric allergic diseases: A Korean nationwide population-based study

Hea-Kyoung Yang1, Jaehee Choi, Woo Kyung Kim

  • 13Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Allergy and Asthma Proceedings
|July 13, 2016
PubMed

Insights

Low vitamin D levels are common in Korean schoolchildren and linked to increased symptoms of atopic dermatitis (AD) and allergic rhinitis (AR). This study highlights the association between vitamin D insufficiency and allergic disease prevalence in children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Science
  • Public Health

Background:

  • The relationship between vitamin D and allergic diseases remains debated.
  • Understanding this link is crucial for public health initiatives.

Purpose of the Study:

  • To examine the association between serum vitamin D levels and recent allergic disease symptoms in elementary schoolchildren.
  • Investigate vitamin D status in a large cohort of young children.

Main Methods:

  • A nationwide cross-sectional survey of 3720 children aged 6-7 years.
  • Diagnoses of atopic dermatitis (AD), asthma, and allergic rhinitis (AR) based on medical treatment and physical examination.
  • Serum 25-hydroxyvitamin D (25[OH]D) levels measured via chemiluminescent immunoassay.

Main Results:

  • High prevalence of vitamin D insufficiency (64.0%) and deficiency (18.4%) observed.
  • Lower vitamin D levels correlated with increased odds of allergic rhinitis and current atopic dermatitis.
  • A significant association was found between lower vitamin D and positive skin-prick test reactivity.

Conclusions:

  • Korean elementary schoolchildren exhibit a high prevalence of vitamin D deficiency and insufficiency.
  • Low serum vitamin D levels are associated with recent symptoms of atopic dermatitis and allergic rhinitis in this population.
Abstract

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