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Serum clusterin level in children with atopic dermatitis
In Suk Sol1, Yoon Hee Kim, Kyung Eun Lee
1Department of Paediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Allergy and Asthma Proceedings
|July 13, 2016
Summary
Serum clusterin levels are elevated in children with atopic dermatitis (AD) and correlate with disease severity. This suggests clusterin may serve as a biomarker for AD in pediatric patients.
Area of Science:
- Biochemistry
- Immunology
- Dermatology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- Clusterin, a cellular biosensor of oxidative stress, is implicated in inflammatory diseases.
- Previous research has not evaluated clusterin levels in pediatric AD.
Purpose of the Study:
- To investigate serum clusterin levels in children diagnosed with atopic dermatitis.
- To determine the association between serum clusterin concentrations and the severity of atopic dermatitis.
Main Methods:
- A cohort of 140 children (100 with AD, 40 healthy controls) was studied.
- Atopic dermatitis severity was assessed using the SCORing Atopic Dermatitis (SCORAD) index.
- Serum clusterin levels were quantified via enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Children with AD exhibited significantly higher serum clusterin levels compared to healthy controls (p = 0.001).
- Serum clusterin concentrations demonstrated a positive correlation with the SCORAD index (r = 0.327, p = 0.002).
Conclusions:
- Elevated serum clusterin levels are observed in children with atopic dermatitis.
- Increased clusterin levels correlate with greater AD severity, indicating its potential as a biomarker.
