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Related Experiment Videos

Time to move the fat.

Benjamin P Weaver1, Aileen K Sewell1, Min Han1

  • 1Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.

Genes & Development
|July 13, 2016
PubMed
Summary
This summary is machine-generated.

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Developmental timing and lipid mobilization are linked in adult C. elegans. This study reveals cross-tissue signaling from the hypodermis to the intestine, crucial for reproductive success.

Area of Science:

  • Physiology
  • Developmental Biology
  • Genetics

Background:

  • Physiological transitions to adulthood involve complex regulatory networks.
  • Lipid metabolism and developmental timing have been studied as separate processes.

Purpose of the Study:

  • To investigate the connection between developmental timing and lipid mobilization in *Caenorhabditis elegans*.
  • To identify the genetic basis and signaling pathways linking these two physiological aspects.

Main Methods:

  • Genetic analysis in *Caenorhabditis elegans*.
  • Observation of physiological changes during the transition to adulthood.
  • Cross-tissue signaling studies involving hypodermis and intestine.

Main Results:

Keywords:
fat metabolisminsulinmTORC2microRNAspqm-1vitellogenesis

Related Experiment Videos

  • Significant genetic evidence supports a link between developmental timing and lipid mobilization.
  • Cross-tissue signaling from the hypodermis to the intestine was identified.
  • This signaling pathway is critical for reproductive success.

Conclusions:

  • Developmental timing decisions directly influence lipid mobilization.
  • A novel signaling axis from the hypodermis to the intestine regulates lipid metabolism.
  • This mechanism ensures reproductive success during the transition to adulthood.