Related Experiment Video
Updated: Mar 18, 2026
09:49
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
Published on: December 28, 2021
4.0K
Adipose-Derived Regenerative Cell Injection Therapy for Postprostatectomy Incontinence: A Phase I Clinical Study
Jae Young Choi1, Tae Hwan Kim2, Jung Dug Yang3
1Department of Urology, College of Medicine, Yeungnam University, Daegu, Korea.
Yonsei Medical Journal
|July 13, 2016
Summary
Transurethral injection of autologous adipose-derived regenerative cells (ADRCs) offers a safe and effective treatment for post-prostatectomy urinary incontinence, improving leakage and urethral function.
Area of Science:
- Regenerative Medicine
- Urology
- Cell Therapy
Background:
- Post-prostatectomy urinary incontinence is a common complication affecting quality of life.
- Current treatments have limitations, necessitating novel therapeutic approaches.
Purpose of the Study:
- To evaluate the safety and efficacy of transurethral injection of autologous adipose-derived regenerative cells (ADRCs) for treating urinary incontinence after radical prostatectomy.
Main Methods:
- Six men with post-prostatectomy incontinence received transurethral injections of autologous ADRCs and adipose tissue.
- Assessments included 24-h pad tests, patient questionnaires, urethral pressure profiles, and MRI over 12 weeks.
Main Results:
- Significant improvement in urine leakage and subjective symptoms was observed.
- Mean maximum urethral closing pressure increased, and functional urethral length improved.
- No adverse events such as pain, inflammation, or urgency were reported.
Conclusions:
- Transurethral injection of autologous ADRCs is a safe and effective treatment for post-prostatectomy incontinence.
- This cell-based therapy shows promise for restoring urethral function.
