Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Renal diseases and platelet activating factor].

E Pirotzky1, P Colliez, C Guilmard

  • 1Institut Henri-Beaufour Research Labs, Les Ulis, France.

Pediatrie
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison between endothelial and neuronal nitric oxide pathways in rat aorta and gastric fundus.

Nitric oxide : biology and chemistry·1998
Same author

Pharmacological characterization of alpha 1-adrenoceptor subtype mediating regulation of arterial pressure and urethral perfusion pressure in the anaesthetized rat.

Journal of autonomic pharmacology·1996
Same author

Structure-activity relationships in platelet-activating factor (PAF). 7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonistic activity.

Journal of lipid mediators and cell signalling·1996
Same author

Structure-activity relationships in platelet-activating factor (PAF). 8. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors: anti-acetylcholinesterase activity and comparative SAR.

Journal of lipid mediators and cell signalling·1996
Same author

Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·1996
Same author

Role of platelet activating factor in kidney transplant rejection in the rat.

Kidney international·1995

Platelet-activating factor (PAF) contributes to inflammation and kidney diseases like proteinuria. PAF antagonists offer potential therapeutic value for treating these nephropathies.

Area of Science:

  • Biochemistry
  • Immunology
  • Nephrology

Background:

  • Platelet-activating factor (PAF) is a pro-inflammatory mediator synthesized by various cells, including monocytes, platelets, and endothelial cells.
  • PAF plays a significant role in diverse inflammatory conditions such as allergies, cerebral, cardiac, and renal ischemia.
  • Its involvement in pathophysiological processes necessitates a deeper understanding of its mechanisms.

Purpose of the Study:

  • To elucidate the role of Platelet-Activating Factor (PAF) in inflammatory and nephropathic conditions.
  • To explore the therapeutic potential of PAF antagonists in managing PAF-mediated disorders.
  • To investigate the specific involvement of PAF in the pathogenesis of proteinuria.

Main Methods:

  • Review of existing literature on PAF synthesis, function, and antagonists.

Related Experiment Videos

  • Analysis of studies investigating PAF's role in inflammatory diseases.
  • Examination of research on PAF's implication in nephropathies, particularly proteinuria.

    • Main Results:

    • PAF is implicated in a wide array of inflammatory responses and ischemic events.
    • Specific PAF antagonists have been instrumental in deciphering its pathophysiological effects.
    • Evidence suggests PAF is a key factor in the development of proteinuria and other kidney diseases.

    Conclusions:

    • PAF is a critical mediator in various inflammatory and ischemic conditions.
    • The development of PAF antagonists has significantly advanced the understanding of PAF's role in human diseases.
    • PAF antagonists represent a promising therapeutic strategy for treating proteinuria and related nephropathies.