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CD28 days later: Resurrecting costimulation for CD8(+) memory T cells.

Verena van der Heide^1,2, Dirk Homann^1,2

¹Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

European Journal of Immunology

|July 13, 2016

Summary

Optimal CD8(+) T-cell memory recall responses require CD28 signaling. This study confirms CD28 costimulation is essential for robust CD8(+) T-cell memory cell expansion and function.

Keywords:

CD28 CD8+ T cell T-cell memory costimulation

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Area of Science:

Immunology
Cellular immunology
T-cell biology

Background:

CD8(+) T cells are crucial for adaptive immunity, providing enhanced protection upon antigen re-encounter.
The precise requirements for costimulation, especially CD28 signaling, in CD8(+) T-cell memory (CD8(+) TM) recall responses are not fully understood.

Purpose of the Study:

To definitively establish the role of CD28 signaling in CD8(+) TM cell recall responses.
To explore the complexities of CD28-dependent interactions shaping T-cell function.

Main Methods:

Investigated CD8(+) TM cell recall responses.
Analyzed the impact of CD28 signaling on T-cell activation and proliferation.

Main Results:

Provided definitive evidence that optimal CD8(+) TM cell recall responses are contingent on CD28 expressed by these cells.
Highlighted the critical role of CD28 in T-cell memory elaboration.

Conclusions:

CD28 costimulation is essential for effective CD8(+) T-cell memory recall.
Further research is needed to fully elucidate CD28-dependent interactions in shaping T-cell phenotypes and functions.