Related Experiment Video
Updated: Mar 18, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Left Ventricular Hypertrophy in Children with Hypertension: in Search of a Definition
Christine B Sethna1, Daniel E Leisman2
1Division of Pediatric Nephrology, Cohen Children's Medical Center of New York, 269-01 76th Avenue, 11040, New Hyde Park, NY, USA. csethna@northwell.edu.
Insights
Left ventricular hypertrophy (LVH) in hypertensive children lacks a standardized definition, leading to varied diagnostic approaches. Establishing a consensus is crucial for accurate pediatric hypertension management.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Imaging
- Hypertension Research
Background:
- Left ventricular hypertrophy (LVH) is a significant concern in pediatric hypertension.
- Accurate diagnosis and management of LVH are critical for long-term cardiovascular health in children.
Purpose of the Study:
- To review the importance of LVH in pediatric hypertension.
- To highlight diagnostic methods and challenges in defining pediatric LVH.
- To emphasize the need for standardization and a consensus definition for LVH in children.
Main Methods:
- Review of current literature on pediatric LVH diagnosis.
- Analysis of variations in imaging modalities and measurement techniques.
- Examination of methods for left ventricular mass (LVM) calculation and indexing.
Main Results:
- Significant variation exists in the definition and assessment of pediatric LVH.
- Inconsistent approaches are noted in imaging, measurement, indexing, normalization, and reference data.
- Lack of consensus hinders consistent clinical practice and reporting.
Conclusions:
- There is a critical need for a standardized definition and diagnostic approach for LVH in pediatric hypertension.
- Standardization will improve accuracy in LVH assessment and patient management.
- A consensus definition is essential for advancing research and clinical care in pediatric cardiovascular health.
Purpose Of Review:
The purpose of this review is to provide background on the importance of left ventricular hypertrophy (LVH) in children with hypertension, to highlight various diagnostic modalities and measures for defining LVH, and to demonstrate the need for standardization and a consensus definition for LVH in the pediatric population.
Recent Findings:
There is no clear consensus among specialists performing echocardiograms and treating clinicians on the definition of LVH in children with hypertension. In fact, there is considerable variation in every step of the evaluation of pediatric LVH. There is variation in every step of the assessment of LVH in the pediatric population. This variation exists in imaging modality, the type of measurement used, the method of calculating left ventricular mass (LVM), the method of indexing LVM to body size, the normalization method for the index used, the reference data used, the inclusion of confounders, the implementation in clinical practice, and the format for echocardiography reporting.
More Related Videos
06:04Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
Published on: June 9, 2023
07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Heart Failure II: Pathophysiology
Mitral Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Cardiomyopathy V: Interprofessional Care