Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.7K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.7K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.9K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

10.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.2K
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

19.0K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
19.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.9K
Overview
85.9K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

11.4K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serotonin 5-HT7 receptor signaling modulates inflammatory responses and survival after myocardial infarction.

Journal of translational medicine·2026
Same author

Concomitant liver steatosis in chronic HBV infection is linked to a distinct cytokine profile and reduced viral load.

The Journal of infectious diseases·2026
Same author

An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation.

npj aging·2026
Same author

Post-Acute Sequelae Patients with Severe COVID-19 History Show a Prolonged Inflammatory, Vascular Injury Pattern.

European journal of immunology·2026
Same author

Disturbed regulation of immunothrombosis in cerebral ischemia associated with SARS-CoV-2 infection.

Frontiers in immunology·2026
Same author

Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D.

JHEP reports : innovation in hepatology·2026
Same journal

IL-33 scripts cancer immunity.

Trends in immunology·2026
Same journal

Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

Trends in immunology·2026
Same journal

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

Trends in immunology·2026
Same journal

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease.

Trends in immunology·2026
Same journal

Metabolic regulatory nodes of the inflammasome and inflammatory cell death.

Trends in immunology·2026
Same journal

Parental leave in immunology - 6.

Trends in immunology·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.7K

T Cells Going Innate.

Midas Seyda1, Abdallah Elkhal2, Markus Quante2

  • 1Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany.

Trends in Immunology
|July 13, 2016
PubMed
Summary
This summary is machine-generated.

Natural killer cell receptors (NKRs) can confer innate-like properties to T cells, particularly in chronic inflammation. These NKRs may drive T cell responses independently of CD28, impacting allograft rejection and immunosuppression resistance.

Keywords:
NK cell receptorsT cellsadaptive immunityinnate immunitytransplantation

More Related Videos

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

6.7K
Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

54.8K

Related Experiment Videos

Last Updated: Mar 18, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.7K
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

6.7K
Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

54.8K

Area of Science:

  • Immunology
  • Transplantation Immunology
  • T cell biology

Background:

  • Antigen-experienced T cells can alter their receptor repertoire to include Natural Killer (NK) cell receptors (NKRs) under prolonged stimulation.
  • Chronic antigen exposure is linked to the loss of CD28 costimulatory molecules and increased antigen thresholds in CD8(+) T cells.
  • NKRs have been implicated in allograft rejection, operating independently of CD28.

Purpose of the Study:

  • To discuss the role of CD28-negative T cells expressing NKRs in allorecognition.
  • To explore how NKRs provide alternative costimulatory pathways in chronic inflammation.
  • To examine the potential for NKR-expressing T cells to resist CD28-targeting immunosuppression.

Main Methods:

  • Review and discussion of existing literature on T cell receptor (TCR) repertoire changes, NKRs, CD28 expression, and transplantation.
  • Analysis of mechanisms by which NKRs might mediate T cell activation, including TCR crossreactivity and TCR-independent pathways.
  • Conceptual framework for understanding innate-like T cell function in chronic inflammatory settings.

Main Results:

  • CD28-negative T cells can acquire NKR functionality, potentially promoting allorecognition.
  • Allorecognition can be mediated by TCR crossreactivity or independently of TCR recognition.
  • NKRs provide alternative costimulatory pathways relevant in chronic inflammation.

Conclusions:

  • NKRs can induce innate-like properties in T cells, offering alternative costimulatory signals.
  • These NKR-expressing T cells may contribute to allograft rejection via CD28-independent mechanisms.
  • The acquisition of NKRs by T cells could lead to resistance against CD28-targeting immunosuppressive therapies.