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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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Prophylaxis of vertical HBV infection
Malgorzata Pawlowska1, Anna Pniewska1, Malgorzata Pilarczyk1
1a Department of Pediatric Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum Bydgoszcz , Nicolaus Copernicus University , Toruń , Poland.
Expert Opinion on Drug Safety
|July 13, 2016
Summary
Preventing mother-to-child transmission of Hepatitis B virus (HBV) is key to reducing chronic infections. Comprehensive strategies including screening, antiviral therapy, and infant immunoprophylaxis are vital for pregnant women with HBV.
Area of Science:
- Hepatology
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Hepatitis B virus (HBV) infection management is crucial for reducing global disease burden.
- Mother-to-child transmission (MTCT) accounts for over a third of chronic HBV infections.
- Infancy or early childhood HBV infection frequently leads to chronic disease, necessitating prenatal prevention.
Purpose of the Study:
- To outline essential strategies for preventing vertical transmission of HBV.
- To emphasize the importance of managing HBV in pregnant individuals.
Main Methods:
- Universal screening of pregnant women for HBV infection.
- Administration of antivirals in the third trimester for high viral load cases.
- Passive-active immunoprophylaxis for newborns using hepatitis B vaccine and immune globulin.
Main Results:
- Universal screening, early HBV DNA level identification, and maternal antiviral treatment are key.
- Passive-active immunoprophylaxis in newborns of HBV-positive mothers is critical.
- Cesarean section may be considered for high-risk pregnancies despite therapy.
Conclusions:
- Comprehensive management including screening, timely treatment, and neonatal prophylaxis significantly reduces HBV vertical transmission.
- Antiviral therapy and appropriate delivery methods are essential components of HBV prevention in pregnancy.
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