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Updated: Mar 18, 2026

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Perioperative Pain Management Strategies for Amputation: A Topical Review
Michael L Kent1, Hung-Lun John Hsia2, Thomas J Van de Ven2
1Department of Anesthesiology, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Effective acute pain management after amputation requires tailored, catheter-based techniques and a multidisciplinary approach. This strategy is crucial for alleviating residual limb and phantom limb pain in the immediate postoperative setting.
Area of Science:
- Pain Management
- Surgical Recovery
- Amputation Care
Background:
- Amputation patients experience significant acute residual limb and phantom limb pain.
- Existing research often prioritizes long-term pain prevention over immediate postoperative outcomes.
- Perioperative pharmacologic agents and interventional techniques have been explored for pain relief.
Purpose of the Study:
- To review acute pain management strategies for amputation patients.
- To consider preoperative factors, pharmacologic/interventional modalities, and multidisciplinary care.
- To alleviate immediate post-amputation suffering.
Main Methods:
- Focused literature review.
- Examination of pharmacologic agents (gabapentin, ketamine, calcitonin).
- Evaluation of interventional modalities (neuraxial and perineural catheters).
Main Results:
- Pharmacologic agents showed inconsistent efficacy.
- Neuraxial analgesia offered opioid-sparing and analgesic benefits.
- Perineural catheters showed mixed results, with potential benefits from prolonged use and improved techniques.
Conclusions:
- Patient-tailored, catheter-based analgesic regimens are essential for acute post-amputation pain.
- A multidisciplinary approach is necessary for optimal patient care.
- Future research should compare effective analgesic regimens and improve acute pain measurement.
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