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Valproate Induced Hypertensive Urgency.

Mauran Sivananthan1, Sarah Mohiuddin1

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Case Reports in Psychiatry
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PubMed
Summary
This summary is machine-generated.

Valproate medication can cause hypertensive urgency, a dangerous rise in blood pressure, in children. Stopping the drug stabilized the patient's blood pressure, highlighting a critical safety concern.

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Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Valproate is a widely prescribed anticonvulsant and mood-stabilizing medication.
  • Hypertension is a potential adverse effect of various medications, but less commonly reported with valproate.

Purpose of the Study:

  • To report a case of hypertensive urgency in a child initiated on valproate.
  • To raise awareness among clinicians regarding this potential adverse effect.

Main Methods:

  • Case report of an 8-year-old male patient.
  • Clinical observation of blood pressure response to valproate initiation and discontinuation.

Main Results:

  • The patient developed hypertensive urgency shortly after starting valproate therapy.
  • Initial antihypertensive treatments were ineffective.
  • Blood pressure normalized upon cessation of valproate.

Conclusions:

  • Valproate may be associated with the risk of precipitating hypertensive urgency in pediatric patients.
  • Clinicians should monitor blood pressure closely in children receiving valproate, especially those with pre-existing risk factors for hypertension.
  • Discontinuation of valproate should be considered in cases of unexplained severe hypertension during treatment.