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Arginine and Caries Prevention: A Systematic Review
Álfheiður Ástvaldsdóttir1, Aron Naimi-Akbar, Thomas Davidson
1Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Caries Research
|July 13, 2016
Summary
Current evidence does not support arginine in toothpaste for preventing cavities. More independent research is needed to confirm any caries-preventive effects of arginine-containing dental products.
Area of Science:
- Dental Science
- Caries Prevention Research
- Evidence-Based Dentistry
Background:
- Dental caries remains a significant public health concern.
- Arginine is an amino acid proposed to have anticaries properties.
- The efficacy of arginine in dental care products requires rigorous evaluation.
Purpose of the Study:
- To systematically review evidence on arginine-containing dental products for caries prevention.
- To assess the impact of arginine on new caries lesion development and existing lesion progression.
Main Methods:
- Systematic literature search of PubMed, Cochrane Library, and EMBASE.
- Inclusion of randomized controlled trials (RCTs) of arginine in fluoride toothpaste.
- Independent assessment of study quality and risk of bias using GRADE classification.
Main Results:
- No conclusions on arginine-fluoride toothpaste efficacy in children due to conflicts of interest and limited applicability.
- Arginine toothpaste is significantly more expensive than standard fluoride toothpaste.
- Ethical concerns noted in some studies, with control groups using non-fluoridated toothpaste.
Conclusions:
- Insufficient evidence currently supports the caries-preventive effect of arginine in toothpastes.
- Further high-quality, independent research is necessary to establish efficacy.
- Cost-effectiveness of arginine toothpaste remains undetermined without proven additional benefits.
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