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The pathogenesis of multifocal osteonecrosis.
Wei Sun1, Zhencai Shi1, Fuqiang Gao1
1Centre for Osteonecrosis and Joint-preserving &Reconstruction, Orthopaedic Department, China-Japan Friendship Hospital, Beijing, 100029, China.
Scientific Reports
|July 13, 2016
Summary
Early radiological screening for multifocal osteonecrosis (MFON) in high-risk patients significantly increased MFON incidence detection. Prompt diagnosis and treatment of MFON are crucial for optimal patient outcomes.
Area of Science:
- Orthopedics
- Radiology
- Medical Diagnostics
Background:
- Multifocal osteonecrosis (MFON) presents diagnostic challenges.
- Early identification of MFON is critical for effective treatment and improved patient prognosis.
Purpose of the Study:
- To investigate the incidence, etiology, and diagnostic methods for MFON.
- To optimize treatment strategies for MFON through earlier diagnosis.
Main Methods:
- Radiological investigation of osteonecrosis patients at high risk for MFON.
- Magnetic resonance imaging (MRI) of asymptomatic joints in at-risk patients.
- Radiological screening of 102 high-risk patients with a prior negative MFON diagnosis.
Main Results:
- MFON incidence increased from 3.1% to 5.2% during the study period.
- An additional 31 MFON cases (30.4%) were identified through screening high-risk patients.
- Targeted radiological examination of other joints is effective in detecting MFON.
Conclusions:
- Systematic radiological examination of other joints in high-risk osteonecrosis patients is essential.
- This approach reduces missed MFON diagnoses, enabling earlier intervention.
- Optimized diagnosis and treatment of MFON lead to better patient outcomes.
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