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Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations:

S Bakshi1, E C de Lange1, P H van der Graaf1,2

  • 1Systems Pharmacology, Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.

CPT: Pharmacometrics & Systems Pharmacology
|July 13, 2016
PubMed
Summary

This tutorial explores dynamical systems analysis for complex models. Mathematical analysis of a nonlinear precursor-pool model reveals insights into multiple steady states and parameter regions beyond simulation capabilities.

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