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Randomized Experiments

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...

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Related Experiment Video

Updated: Mar 18, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

The Deckled Incision: Study Protocol for a Randomized Controlled Trial.

Apresh Singla¹, Sarah J Lord, Quan Ngo

¹St Vincents Hospital, Sydney, Australia. apresh.singla@gmail.com.

JMIR Research Protocols

|July 14, 2016

Summary

This summary is machine-generated.

This study investigates if irregular "deckled" skin incisions improve scar appearance compared to straight incisions. Early results suggest deckled incisions yield superior cosmetic outcomes for plastic surgery patients.

Keywords:

post-operative scar improvement

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Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

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Published on: December 23, 2022

Area of Science:

Plastic Surgery
Dermatology
Wound Healing

Background:

Scar visibility is influenced by multifactorial elements, with skin closure techniques playing a key role.
Z-plasties are known to reduce scar contracture by disrupting tension lines.
This study explores if irregular 'deckled' incisions offer aesthetic advantages over traditional straight incisions.

Purpose of the Study:

To evaluate clinician and patient perceptions of scar quality using the Patient and Observer Scar Assessment Scale (POSAS).
To determine the proportion of scars rated as 'good' (POSAS ≤ 5) by both patients and clinicians.
To assess adverse events and scar visibility at one meter.

Main Methods:

A patient-blinded, simple randomized controlled trial (RCT) with equal 1:1 allocation to control (straight incision) and treatment (deckled incision) arms.
Enrollment of 500 patients over 18 undergoing skin lesion excision in plastic surgery.
Exclusion of patients requiring re-excision or corticosteroid therapy, with follow-up at 1 week, 3 months, and 6 months.

Main Results:

The study anticipates superior scar outcomes in the deckled incision group compared to the straight incision group.
Clinical experience suggests particular benefits for facial lesions and skin areas previously treated with radiation therapy.
The study is funded by St. Vincent's Hospital, Sydney, and has obtained ethics approval.

Conclusions:

The deckled incision technique is a novel, simple-to-master method for improving post-operative scar appearance.
This technique is broadly applicable to various surgical procedures and holds potential for generalizability across diverse patient populations.
Further research will validate the aesthetic benefits of deckled incisions in plastic surgery outcomes.