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Ubiquinone-10 plasma concentrations in healthy European children

K Becker1,2, D Boetticher1, M Leichsenring1

  • 1a University Children's Hospital Germany.

Redox Report : Communications in Free Radical Research
|July 14, 2016
PubMed

Insights

Ubiquinone-10 (coenzyme Q), an antioxidant, has established reference ranges in European children. Plasma levels were found to be age-dependent, decreasing with age, but not sex-dependent.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Nutritional Science

Background:

  • Ubiquinone-10 (coenzyme Q) functions as a crucial physiological antioxidant in human blood.
  • Establishing pediatric reference ranges is vital for understanding its role in child health.

Purpose of the Study:

  • To determine the reference range for plasma ubiquinone-10 levels in healthy European infants and children.
  • To investigate potential correlations with age and sex in this pediatric population.

Main Methods:

  • Plasma ubiquinone levels were measured in 50 healthy European children aged 2 months to 15 years.
  • Statistical analysis was performed to assess correlations with age and sex.

Main Results:

  • A mean plasma ubiquinone level of 0.75±0.27 μg/ml was determined.
  • Concentrations showed a negative correlation with age (r = -0.37, P=0.0075), with higher levels in younger children.
  • No significant sex-dependent differences were observed.

Conclusions:

  • The study provides reference values for plasma ubiquinone-10 in European children.
  • Age is a significant factor influencing ubiquinone-10 levels during childhood.
  • These findings contribute to the understanding of antioxidant status in pediatric populations.

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