Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.7K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.4K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.7K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Council for Standardization in Haematology (ICSH) recommendations for the performance and interpretation of activated partial thromboplastin time and prothrombin time mixing tests.

International journal of laboratory hematology·2024
Same author

Misdiagnosis of high thrombotic risk triple-positive antiphospholipid antibodies.

Thrombosis research·2020
Same author

Targeting raised von Willebrand factor levels and macrophage activation in severe COVID-19: Consider low volume plasma exchange and low dose steroid.

Thrombosis research·2020
Same author

Rodenticidal hepatotoxicity: Raised plasma Von Willebrand factor levels predict in-hospital survival and preliminary report of the outcome of Von Willebrand factor reducing management protocol.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2020
Same author

Re: Gorham-Stout disease with involvement of the jaws: a systematic review.

International journal of oral and maxillofacial surgery·2019
Same author

'Corseting' and 'strangling'-two techniques sharing similar concepts to treat large venous malformations in the head and neck region.

International journal of oral and maxillofacial surgery·2018

Related Experiment Video

Updated: Mar 18, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K

Quality laboratory issues in bleeding disorders.

D M Adcock1, J Mammen2, S C Nair2

  • 1Colorado Coagulation, Laboratory Corporation of America® Holdings, Englewood, CO, USA.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|July 14, 2016
PubMed
Summary

Improving haemostasis laboratory testing quality is crucial for accurate diagnoses. This review highlights preanalytical error reduction and specific methods for factor VIII inhibitor testing, benefiting patients with bleeding disorders.

Keywords:
bleedingexternal quality assessment schemesfactor inhibitorslaboratorypreanalyticquality

More Related Videos

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.1K
Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

14.1K

Related Experiment Videos

Last Updated: Mar 18, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.1K
Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

14.1K

Area of Science:

  • Clinical Laboratory Science
  • Haemostasis and Thrombosis
  • Quality Management in Healthcare

Background:

  • Accurate laboratory testing is vital for diagnosing and managing bleeding disorders.
  • Preanalytical errors are a significant source of incorrect test results in haemostasis diagnostics.
  • Quality assessment schemes are essential for ensuring reliable laboratory performance.

Purpose of the Study:

  • To discuss key quality issues in haemostasis laboratory testing.
  • To detail the implementation and impact of an external quality assessment scheme.
  • To review strategies for improving the accuracy of factor VIII inhibitor testing.

Main Methods:

  • Discussion of common preanalytical errors and sample rejection criteria.
  • Description of analytical methods to identify and overcome interferences.
  • Review of quality issues in the determination of factor VIII inhibitors.

Main Results:

  • External quality assessment schemes can significantly improve result accuracy.
  • Preanalytical error mitigation is critical for reliable haemostasis testing.
  • Heat treatment of plasma is recommended for accurate factor VIII inhibitor detection.

Conclusions:

  • Implementing robust quality initiatives enhances laboratory testing for bleeding disorders.
  • Focusing on preanalytical phase improvements and specific analytical techniques is key.
  • Resource-restricted settings can adopt these strategies to improve diagnostic quality.