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Updated: Mar 18, 2026

Microvascular Embolism Mouse Model for In Vivo Two-photon Microscopy Using Fluorescent Polystyrene Microspheres
Published on: November 21, 2025
[Clinical course and differential diagnosis of thrombotic microangiopathy]
1Medizinische Klinik IV, Abteilung für Endokrinologie und Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. martina.guthoff@med.uni-tuebingen.de.
Background:
Thrombotic microangiopathies are complex diseases, requiring early differential diagnosis and targeted intervention.
Objectives:
Presentation of clinical phenotype and diagnostic algorithm, discussion of underlying pathophysiology, clinical management and therapy.
Methods:
Summary of current knowledge from literature and expert opinion.
Results:
Our understanding of pathophysiology and therapeutic options have changed substantially in recent years. Early differential diagnosis and targeted therapy are of prognostic relevance.
Conclusions:
A better understanding of underlying pathophysiology, increased clinical awareness and novel therapeutic options allow for a better prognosis of patients with thrombotic microangiopathy.
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