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Extensive structural homology between H-2 K/D/L antigens and non-polymorphic class I Qa, Tla and "37" molecules
A Prochnicka-Chalufour1, J L Casanova, P Kourilsky
1Unité Informatique Scientifique, Institut Pasteur, Paris.
Research in Immunology
|February 1, 1989
Abstract:
Key structural features of H-2 K/D/L and HLA A/B/C class I molecules were identified by analysing the available sequences with reference to the 3-D structure of HLA-A2. Most of them were found to be conserved in a panel of 6 Qa and 4 Tla sequences. This finding, in addition to the high overall sequence similarity between polymorphic and non-polymorphic class I molecules strongly suggests a possible role for the latter in peptide binding, transport and/or presentation.