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Topical glycopyrrolate reduces axillary hyperhidrosis.

D M Baker1

  • 1Department of Surgery, Royal Free Hospital, London, UK.

Journal of the European Academy of Dermatology and Venereology : JEADV
|July 14, 2016
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Topical glycopyrrolate spray effectively treats axillary hyperhidrosis. Both 2% glycopyrrolate spray and Botulinum toxin type A injections significantly improved symptoms, offering new treatment options for excessive sweating.

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Area of Science:

  • Dermatology
  • Clinical Pharmacology

Background:

  • Oral anticholinergics manage generalized hyperhidrosis.
  • Effectiveness of topical anticholinergics for axillary hyperhidrosis is not well-established.

Purpose of the Study:

  • Evaluate topical glycopyrrolate spray (1% and 2%) for axillary hyperhidrosis.
  • Compare its efficacy against Botulinum toxin type A injections.

Main Methods:

  • Non-randomized, prospective study of 40 axillary hyperhidrosis patients.
  • Four groups: 1% glycopyrrolate, 2% glycopyrrolate, Botulinum toxin A, or no treatment.
  • Questionnaire assessed outcomes pre-treatment and at 6 weeks.

Main Results:

  • All three treatments significantly improved hyperhidrosis scores (P < 0.05).
  • 2% glycopyrrolate showed comparable outcomes to Botulinum toxin A.
  • 1% glycopyrrolate was less effective than Botulinum toxin A.
  • Both 2% glycopyrrolate and Botulinum toxin A improved psychological and physical symptoms.

Conclusions:

  • Topical glycopyrrolate spray is a viable treatment for axillary hyperhidrosis.
  • 2% concentration demonstrates significant efficacy comparable to Botulinum toxin A.
  • Offers a new therapeutic option for managing excessive underarm sweating.