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Related Experiment Video

Updated: Mar 18, 2026

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

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Resolving Myocardial Activation With Novel Omnipolar Electrograms.

Stéphane Massé¹, Karl Magtibay¹, Nicholas Jackson¹

¹From the The Hull Family Cardiac Fibrillation Management Laboratory and University Health Network, Toronto General Hospital, Toronto, ON, Canada (S.M., K.M., N.J., J.A., M.K., K.N.); St. Jude Medical, St. Paul, MN (R.B., D.C.D.); and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada (B.Z., M.R.).

Circulation. Arrhythmia and Electrophysiology

|July 14, 2016

Summary

Omnipolar electrograms provide accurate, electrode-independent measurements of cardiac conduction velocity and direction. This novel method enables precise localization of arrhythmia sources without needing local activation times.

Keywords:

cardiac arrhythmia cardiac electrophysiology catheter ablation conduction velocity omnipole

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Last Updated: Mar 18, 2026

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

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High-Throughput Analysis of Optical Mapping Data Using ElectroMap

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Published on: June 4, 2019

Area of Science:

Cardiovascular physiology
Biomedical engineering
Electrophysiology

Background:

Traditional cardiac mapping relies on local activation times, which have inherent limitations.
Omnipolar electrograms offer a new approach to cardiac mapping.
This method bypasses the need for determining local activation times.

Purpose of the Study:

To introduce and validate omnipolar electrograms for cardiac mapping.
To compute instantaneous conduction velocity, amplitude, and direction.
To explore the application of omnipolar electrograms in localizing arrhythmia sources.

Main Methods:

Omnipolar electrograms were derived and validated using diverse models: cell preparations, 3D cardiomyocyte constructs, rabbit hearts, and in vivo pig studies.
Both optical and electrical signal acquisition methodologies were employed.
Conduction velocities were compared against traditional local activation time methods using Bland-Altman analysis.

Main Results:

Omnipolar measurements showed agreement with local activation time methods for wavefront direction (within 30°) and velocity (within 25 cm/s) on both optical and electrical data.
Mathematical operations (curl, divergence) applied to omnipolar-derived velocity vector fields successfully located rotational and focal sources.
The technique proved electrode orientation-independent.

Conclusions:

Omnipolar electrograms accurately determine cardiac wavefront trajectory and speed at a single location, independent of electrode orientation.
Combined with mathematical transforms, omnipolar-derived vector fields can potentially aid in real-time detection of cardiac activation sources.
This technology offers a promising advancement for cardiac mapping and arrhythmia localization.