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Modulation of Platelet Aggregation Response by Factors Released from Polymorphonuclear Leukocytes
1a Pharmacology Division , Central Druo Research Institute , Lucknow - 226001 India.
Hematology (Amsterdam, Netherlands)
|July 14, 2016
Summary
Polymorphonuclear leukocytes (PMNLs) release mediators that influence platelet aggregation. This review details how PMNL-derived factors, including free radicals and platelet-activating factor, affect platelet responses.
Area of Science:
- Hematology
- Immunology
- Cell Biology
Background:
- Platelets and polymorphonuclear leukocytes (PMNLs) interact, with both cell types releasing mediators.
- These mediators can modulate the reactivity of platelets and PMNLs under various experimental conditions.
Purpose of the Study:
- To review the effects of mediators released from PMNLs on platelet aggregation.
- To summarize studies on PMNL-derived mediators and their impact on platelet function.
Main Methods:
- Literature review of in vitro studies.
- Analysis of mediator release from PMNLs.
- Assessment of mediator effects on platelet aggregation.
Main Results:
- PMNLs release diverse mediators including free radicals, arachidonic acid metabolites, platelet-activating factor (PAF), proteases, nitric oxide, and ectonucleotidases.
- These mediators significantly influence platelet aggregation responses.
Conclusions:
- PMNL-derived mediators play a crucial role in modulating platelet aggregation.
- Understanding these interactions is vital for comprehending inflammatory and thrombotic processes.
Keywords:
Arachidonic acid and its metabolitesNitric oxide and Ecto-ADPasePlatelet activating factorPlateletsPolymorphonuclear leukocytesProteasesReactive oxygen speciesMore Related Videos
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