A model to predict anti-tuberculosis activity: value proposition for marine microorganisms
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Updated: Mar 18, 2026
Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
Published on: October 8, 2018
Miaomiao Liu1,2,3, Tanja Grkovic1, Lixin Zhang2
1Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia.
Abstract:
The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.
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