Related Experiment Video

Updated: Mar 18, 2026

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

12.4K

Concepts to Target MYC in Pancreatic Cancer

Matthias Wirth1, Siavosh Mahboobi2, Oliver H Krämer3

  • 1II. Medizinische Klinik, Technische Universität München, München, Germany.

Molecular Cancer Therapeutics
|July 14, 2016
PubMed

Insights

Pancreatic cancer (PDAC) is driven by MYC signaling. Novel MYC inhibitors are being developed to target this aggressive cancer, offering new therapeutic strategies for patients with poor prognoses.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) presents a poor prognosis with limited effective targeted therapies.
  • The MYC signaling pathway is recognized as a key driver in PDAC development and progression.
  • Current therapeutic strategies for PDAC lack significant clinical impact, highlighting the need for novel approaches.

Purpose of the Study:

  • To review recent advancements in the development of MYC inhibitors for pancreatic cancer.
  • To discuss the potential mechanisms of action for these novel MYC-targeting agents in PDAC.
  • To explore new therapeutic concepts for targeting MYC and other drivers like KRAS in PDAC.

Main Methods:

  • Literature review of recent studies on MYC inhibitors.
  • Analysis of the mode of action of direct and indirect MYC inhibitors.
  • Discussion of the relevance of MYC inhibition in the context of PDAC.

Main Results:

  • MYC is a critical signaling hub and driver in pancreatic ductal adenocarcinoma.
  • No targeted therapies have shown significant clinical benefit against PDAC to date.
  • Recent developments include direct and indirect MYC inhibitors with potential therapeutic applications.

Conclusions:

  • Targeting MYC represents a promising strategy for novel pancreatic cancer therapies.
  • Understanding the mode of action of MYC inhibitors is crucial for their clinical application.
  • Further research into MYC-targeted therapies could improve outcomes for PDAC patients.

More Related Videos

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer06:20

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer

Published on: October 4, 2022

4.1K
An Orthotopic Resectional Mouse Model of Pancreatic Cancer07:17

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

12.9K

Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K