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Updated: Mar 18, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Multiple pulmonary rheumatoid nodules
Gokhan Sargin1, Taskin Senturk1
1Department of Rheumatology, Medical Faculty, Adnan Menderes University, Aydin, Turkey.
Reumatologia
|July 14, 2016
Summary
This case study highlights a rheumatoid arthritis patient who developed lung nodules. Diagnosis involved lung biopsy, and treatment with rituximab led to significant symptom improvement.
Area of Science:
- Rheumatology
- Pulmonology
- Pathology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- RA can manifest with extra-articular complications, including lung involvement.
- Rheumatoid nodules are a known, though less common, manifestation of RA.
Purpose of the Study:
- To present a case of rheumatoid arthritis with pulmonary rheumatoid nodules.
- To illustrate the diagnostic process and histopathological findings.
- To demonstrate the efficacy of rituximab in managing this complication.
Main Methods:
- A 45-year-old female patient with seropositive RA and disease activity score (DAS 28) of 6.9 was evaluated.
- Physical examination and chest X-ray were performed.
- A lung biopsy was conducted for histopathological diagnosis.
- Treatment with rituximab was initiated.
Main Results:
- Physical examination revealed abnormal lung auscultation.
- Chest X-ray showed multiple bilateral lung nodular densities.
- Lung biopsy confirmed necrotizing granulomas, characteristic of rheumatoid nodules.
- The patient experienced significant clinical improvement after rituximab therapy.
Conclusions:
- Pulmonary rheumatoid nodules can occur in patients with rheumatoid arthritis.
- Histopathological examination is crucial for diagnosis.
- Rituximab can be an effective treatment option for rheumatoid arthritis-associated lung nodules.
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